Ok, so I have some possible answers to explain the effects I observed when taking CBD and my usual cocktail of meds. Because it’s late in my day, I’m not really taking the time to finesse this. This is important to pay attention to for anyone, because if you go to see your doctor to get permission before taking CBD with your medications, the drug guides they look at may just say proceed with caution. We did look up my meds in the same drug guides your doctor is most likely going to use, and none of them said to avoid, they all said just to monitor how it was going because CBD may increase some of the side effects.

Basically, it’s really important for you to know how your medications are metabolized, because depending on how your body reacts and how much of the liver enzyme is inhibited for you personally (and this likely varies from person to person), it can increase the amount of the drug circulating in your body because it’s taking longer to break down. So, yes, CBD can calm down mast cells…but, unless you can take Zyrtec as all of your antihistamines (if you have Mast Cell Activation Syndrome like I do, you’re probably on more than one Zyrtec per day and even more than one antihistamine type), you will need to proceed with caution for any other antihistamine and probably need to be monitored. Part of what I observed was likely due to CBD keeping the antihistamines in my system longer, therefore effectively increasing the amount in my system. Because when I got entirely off the Hydroxyzine, not all of my allergy symptoms were managed by the CBD and Allegra alone. Except when I tried taking Zyrtec instead (that definitely had superior allergy benefits) to see if my tolerance for it has changed. It is important to note that I am still recovering from a virus that Tony still has some nasal symptoms from, and he got sick 4 days before me, so possibly that will change

I still can’t take Zyrtec, it raises my heart rate about 30 bpm, and interferes with my ability to get to REM sleep (causes insomnia for me). With the POTS, both of those are a no go. I left a message for my allergist a few days ago about if he had any safety concerns about all of this before our upcoming appointment to discuss it and haven’t heard back…my appointment to discuss all of this with him isn’t until the end of April. The Allegra likely isn’t a significant problem because only 5% of it metabolizes through the liver. But the Vistaril? His drug guide might not say so (because my husband’s sure don’t), but it actually could be. So. If you have mast cell activation syndrome, yes it can help, but make sure you talk with your doctor about how your drugs are metabolized versus what liver enzymes CBD can inhibit as you are making decisions together about what is best for your body, and if you can switch to Zyrtec and want to try the CBD, that may be the safest route.

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